Celiac plexus block:Is a useful interventional pain management procedure done in upper abdominal malignancy like; pancreatic cancer, hepato-biliary cancer, primary or secondary cancer of liver etc. and chronic pancreatitis & other chronic pancreaticobiliary diseases. It may be permanent (neurolytic) with alcohol or phenol or temporary with local anaesthetics and depo-steroids. It is performed percutaneously, either under fluoroscopic or CT guidance. Most percutaneous blocks are performed through a posterior approach (i.e. the needle is inserted through the skin on the back) though may be done through anterior approach. The most common side effects of celiac plexus block include transient diarrhea and hypotension. Following these procedures, one can expect varying results. Most patients will perceive a reduction in their total pain. Only a subset of patients will have total pain relief, or no relief at all. Celiac plexus block with local anaesthetics and steroids provides temporary relief, which can last from a few weeks up to a few months. Celiac plexus block is typically used for pain reduction in patients with chronic pancreatitis.